Comparative Studies on Skin Permeation of Miconazole Using Different Novel Carriers

Purpose: Miconazole nitrate is a widely used antifungal agent but its use in topical formulation is not efficacious because deep ereated fungal infections are difficult to treat with conventional topical formulation. The purpose of this study was to prepare miconazole incorporated different novel carriers such as liposomes, ethosomes and to compare their in vitro skin permeation studies with plane ointment using skin model. Methods: In vitro release studies of miconazole from the liposomal and ethosomal suspension incorporated ointment to an aqueous receptor phase through pig skin was analyzed spectrophotometrically at a wavelength of 272nm. Results: In vitro skin permeation study results showed that the steady state fluxes of drug was higher in case of ethosomal suspension incorporated ointment as compared to liposomal ointment. Conclusions: Hence ethosomes shows better skin permeation as compared to liposomes.